Title : Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha.

Pub. Date : 2019 Aug 27

PMID : 31405972






2 Functional Relationships(s)
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1 Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRalpha/Folr1), known to be regulated by ligand-activated nuclear receptors. Folic Acid rabaptin, RAB GTPase binding effector protein 2 Mus musculus
2 Cerebral folate delivery primarily occurs at the choroid plexus through FRalpha and PCFT; inactivation of these transport systems can result in very low folate levels in the cerebrospinal fluid causing childhood neurodegenerative disorders. Folic Acid rabaptin, RAB GTPase binding effector protein 2 Mus musculus