Pub. Date : 2019 Oct
PMID : 31401382
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estradiol inhibits fMLP-induced neutrophil migration and superoxide production by upregulating MKP-2 and dephosphorylating ERK. | Superoxides | formyl peptide receptor 1 | Homo sapiens |
| 2 | We found that fMLP significantly induced dHL-60 cell and neutrophil migration and superoxide production, which was inhibited by ERK inhibitor PD98059. | Superoxides | formyl peptide receptor 1 | Homo sapiens |
| 3 | E2 significantly inhibited fMLP-induced dHL-60 cell and neutrophil migration and superoxide production at both physiological and pharmacological concentrations. | Superoxides | formyl peptide receptor 1 | Homo sapiens |
| 4 | Collectively, these results demonstrate that fMLP stimulates neutrophil chemotaxis and superoxide production through activating ERK, and indicate that ER-mediated upregulation of MKP-2 may dephosphorylate ERK and contribute to the inhibitory effect of E2 on neutrophil activation by fMLP. | Superoxides | formyl peptide receptor 1 | Homo sapiens |