Title : Synthesis and biological activity of fluorinated analogues of the DAF-12 receptor antagonist 24-hydroxy-4-cholen-3-one.

Pub. Date : 2019 Nov

PMID : 31400393






1 Functional Relationships(s)
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1 In a previous publication we reported that oxysterols with a shorter side chain (C24) modulate the DAF-12 receptor activity either as partial agonists or, in the case of the C24 alcohol 24-hydroxy-4-cholen-3-one, as an antagonist both in vitro and in vivo. Oxysterols Nuclear hormone receptor family member daf-12 Caenorhabditis elegans