Title : Synthesis and biological evaluation of 1,2,4-triazolidine-3-thiones as potent acetylcholinesterase inhibitors: in vitro and in silico analysis through kinetics, chemoinformatics and computational approaches.

Pub. Date : 2020 Nov

PMID : 31396774






2 Functional Relationships(s)
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1 Pleasingly, synthesized compounds show noteworthy acetylcholinesterase (AChE) inhibitory activity with much lower IC50 values 0.0269 +- 0.0021-1.1725 +- 0.0112 muM than standard Neostigmine methylsulphate. Neostigmine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Pleasingly, synthesized compounds show noteworthy acetylcholinesterase (AChE) inhibitory activity with much lower IC50 values 0.0269 +- 0.0021-1.1725 +- 0.0112 muM than standard Neostigmine methylsulphate. Neostigmine acetylcholinesterase (Cartwright blood group) Homo sapiens