Title : Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia.

Pub. Date : 2019 Oct 10

PMID : 31395602






2 Functional Relationships(s)
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1 Mechanistically, we reveal that PRMT1 methylates FLT3 at arginine (R) residues 972 and 973, and its oncogenic function in MLL-r ALL cells is FLT3 methylation-dependent. Arginine lysine methyltransferase 2A Homo sapiens
2 These results indicate that abolishing FLT3 arginine methylation through PRMT1 inhibition represents a promising strategy to target MLL-r ALL cells. Arginine lysine methyltransferase 2A Homo sapiens