Title : Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell lines.

Pub. Date : 1988 Oct 15

PMID : 3139281






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Aphidicolin, a specific inhibitor of DNA polymerase alpha, showed a dose-dependent capacity to inhibit DNA repair in this system with maximum inhibition of 63% at 4 micrograms/ml. Aphidicolin DNA polymerase alpha 1, catalytic subunit Homo sapiens