Pub. Date : 2019 Aug 6
PMID : 31388677
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined Cr(VI) effects on the p53 pathway in human cells with restored levels of ascorbate that acts as a principal reducer of Cr(VI) in vivo but is nearly absent in standard cell cultures. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 2 | Ascorbate-restored H460 and primary human cells treated with Cr(VI) contained higher levels of p53 and its Ser15 phosphorylation, which were induced by ATR kinase. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 3 | A weak transcription activity of Cr(VI)-upregulated p53 was associated with its low lysine acetylation in the regulatory C-terminal domain, resulting from the inability of Cr(VI) to activate ATM in ascorbate-restored cells. | Ascorbic Acid | tumor protein p53 | Homo sapiens |
| 4 | Thus, p53 activation by ascorbate-metabolized Cr(VI) represents a limited genome-protective response that is defective in upregulation of DNA repair genes and proapoptotic transcripts for elimination of damaged cells. | Ascorbic Acid | tumor protein p53 | Homo sapiens |