Title : Synthesis and biological activity of some transition-state inhibitors of human renin.

Pub. Date : 1988 Sep

PMID : 3137345






1 Functional Relationships(s)
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1 A series of renin inhibitors containing the dipeptide transition state mimics (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-7-methyloctanoic acid (Leu (OH)/Val) and (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-6-cyclohexylhexanoic acid (CHa /(OH)/Val) was prepared. Dipeptides renin Homo sapiens