Title : Developing and Characterization of Chemically Modified RNA Aptamers for Targeting Wild Type and Mutated c-KIT Receptor Tyrosine Kinases.

Pub. Date : 2020 Mar 12

PMID : 31369705






1 Functional Relationships(s)
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1 Interestingly, our data indicated that one candidate aptamer, called V15, can specifically inhibit the in vitro kinase activity of mutant c-KITD816V with an IC50 value that is 9-fold more potent than the sunitinib drug tested under the same conditions. Sunitinib immunoglobulin lambda variable 2-18 Homo sapiens