Pub. Date : 2019
PMID : 31360100
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-kappaB and A2aR Signaling in LPS-Induced THP-1 Macrophages. | Caffeine | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | In the present study, we aimed to investigate the effects of caffeine on NLRP3 inflammasome activation in LPS-induced THP-1 macrophages and to explore the underlying the detailed mechanism. | Caffeine | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | We found that caffeine significantly reduced NLRP3 expression, ASC speck formation, and caspase 1 cleavage and therefore decreased IL-1beta and IL-18 secretion in THP-1 macrophages. | Caffeine | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-kappaB signaling and A2aR-associated ROS production in LPS-induced THP-1 macrophages. | Caffeine | NLR family pyrin domain containing 3 | Homo sapiens |