Title : Mechanisms of NT5C2-Mediated Thiopurine Resistance in Acute Lymphoblastic Leukemia.

Pub. Date : 2019 Oct

PMID : 31358663






1 Functional Relationships(s)
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1 Compared to wildtype NT5C2, mutant proteins showed elevated 5"-nucleotidase activity with a stark preference of thiopurine metabolites over endogenous purine nucleotides, suggesting neomorphic effects specific to thiopurine metabolism. 2-mercaptopyrazine 5'-nucleotidase ecto Homo sapiens