Title : Augmentation of cellular NAD+ by NQO1 enzymatic action improves age-related hearing impairment.

Pub. Date : 2019 Oct

PMID : 31353811






1 Functional Relationships(s)
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1 We elucidated that the reduction of cellular NAD+ during the aging process was an important contributor for ARHL; it facilitated oxidative stress and pro-inflammatory responses in the cochlear tissue through regulating sirtuins that alter various signaling pathways, such as NF-kappaB, p53, and IDH2. NAD transformation related protein 53, pseudogene Mus musculus