Pub. Date : 2019 Jul 23
PMID : 31337751
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination. | Acetates | free fatty acid receptor 2 | Mus musculus |
| 2 | Here, we demonstrate that acetate attenuates inflammasome activation via GPR43 in a Ca2+-dependent manner. | Acetates | free fatty acid receptor 2 | Mus musculus |
| 3 | Through binding to GPR43, acetate activates the Gq/11 subunit and subsequent phospholipase C-IP3 signaling to decrease Ca2+ mobilization. | Acetates | free fatty acid receptor 2 | Mus musculus |
| 4 | Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca2+-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases. | Acetates | free fatty acid receptor 2 | Mus musculus |