Title : The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice.

Pub. Date : 2019 Dec

PMID : 31330218






1 Functional Relationships(s)
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1 Although the ORM homologues in yeast are well-known inhibitors of sphingolipid synthesis, it is still unclear whether and how mammalian ORMDL3 regulates sphingolipid metabolism and whether altered sphingolipid synthesis would be causally related to asthma risk. Sphingolipids ORMDL sphingolipid biosynthesis regulator 3 Homo sapiens