Title : Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals.

Pub. Date : 2019 Sep

PMID : 31327267






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 A relatively small number of gene variants related to loci associated with drug-signaling pathways (KCNK3, SULT1C3, AMH, PDE3A, PLCE1, PRKAG2) with large effect size (-3.5 to +3.5 mm Hg difference in response per allele) and differing allele frequencies in black versus white individuals explained a large proportion of the difference in response to candesartan and hydrochlorothiazide between these groups. Hydrochlorothiazide potassium two pore domain channel subfamily K member 3 Homo sapiens