Pub. Date : 2019 Jul 19
PMID : 31324203
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells. | Fluorouracil | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Xenograft models were established to determine whether exosomal p-STAT3 can induce 5-FU resistance in vivo. | Fluorouracil | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Inhibition of p-STAT3 re-sensitized RKO/P cells to 5-FU via caspase cascade. | Fluorouracil | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Furthermore, p-STAT3 packaged by exosomes from RKO/R cells increased resistance of tumor cells to 5-FU in vivo. | Fluorouracil | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | CONCLUSIONS: Our results reveal a novel mechanism by which p-STAT3-containing exosomes contribute to acquired 5-FU resistance in CRC. | Fluorouracil | signal transducer and activator of transcription 3 | Homo sapiens |