Pub. Date : 2019 Oct 1
PMID : 31322418
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Uptake experiments further showed that HCTZ is transported by hOAT1, hOAT3, hOCT2, and hMATE2-K but not by hMATE1. | Hydrochlorothiazide | solute carrier family 47 member 2 | Homo sapiens |
2 | On the other hand, hOCT2 and hMATE2-K showed much lower affinity for HCTZ. | Hydrochlorothiazide | solute carrier family 47 member 2 | Homo sapiens |
3 | The calculated transport efficiency (kcat/Km) at the single transporter level followed the rank order of hOAT1> hOAT3 > hOCT2 and hMATE2-K, suggesting a major role of organic anion transporters in tubular secretion of HCTZ. | Hydrochlorothiazide | solute carrier family 47 member 2 | Homo sapiens |