Title : Renal secretion of hydrochlorothiazide involves organic anion transporter 1/3, organic cation transporter 2, and multidrug and toxin extrusion protein 2-K.

Pub. Date : 2019 Oct 1

PMID : 31322418






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Uptake experiments further showed that HCTZ is transported by hOAT1, hOAT3, hOCT2, and hMATE2-K but not by hMATE1. Hydrochlorothiazide solute carrier family 47 member 2 Homo sapiens
2 On the other hand, hOCT2 and hMATE2-K showed much lower affinity for HCTZ. Hydrochlorothiazide solute carrier family 47 member 2 Homo sapiens
3 The calculated transport efficiency (kcat/Km) at the single transporter level followed the rank order of hOAT1> hOAT3 > hOCT2 and hMATE2-K, suggesting a major role of organic anion transporters in tubular secretion of HCTZ. Hydrochlorothiazide solute carrier family 47 member 2 Homo sapiens