Title : Oral Delivery of the P2Y12 Receptor Antagonist Ticagrelor Prevents Loss of Photoreceptors in an ABCA4-/- Mouse Model of Retinal Degeneration.

Pub. Date : 2019 Jul 1

PMID : 31319418






2 Functional Relationships(s)
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1 Results: Protection by ticagrelor was demonstrated functionally by using the electroretinogram, as ticagrelor-treated ABCA4-/- mice had increased a- and b-waves compared to untreated mice. Ticagrelor ATP-binding cassette, sub-family A (ABC1), member 4 Mus musculus
2 Conclusions: Oral treatment with ticagrelor protected photoreceptors in the ABCA4-/- mouse, which is consistent with enhanced lysosomal function. Ticagrelor ATP-binding cassette, sub-family A (ABC1), member 4 Mus musculus