Title : The role of an anti-diabetic drug metformin in the treatment of endocrine tumors.

Pub. Date : 2019 Aug

PMID : 31307011






1 Functional Relationships(s)
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1 Preclinical evidence suggests that the primary direct mechanisms of metformin action include inhibition of mitochondrial oxidative phosphorylation via inhibition of both mitochondrial complex I and mitochondrial glycerophosphate dehydrogenase, leading to metabolic stress. Metformin glycerol-3-phosphate dehydrogenase 2 Homo sapiens