Pub. Date : 2019 Sep 15
PMID : 31299271
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | IFN-alpha-2b-treated mice showed increased plasma cholesterol levels together with decreased hepatic cholesterol, both on chow and HF diets. | Cholesterol | interferon alpha | Mus musculus |
2 | IFN-alpha-2b-treated mice showed increased plasma cholesterol levels together with decreased hepatic cholesterol, both on chow and HF diets. | Cholesterol | interferon alpha | Mus musculus |
3 | Interestingly, mice on IFN-alpha-2b treatment secreted smaller VLDL particles highly enriched in cholesterol. | Cholesterol | interferon alpha | Mus musculus |
4 | Mechanistically, we found that IFN-alpha-2b antiobesity effects were related to increased fatty acid oxidation; and its effects on cholesterol metabolism were due to both a decrease in the master cholesterogenic transcription factor SREBP-2 and in the rate limiting enzyme in cholesterol synthesis, HMGCR. | Cholesterol | interferon alpha | Mus musculus |
5 | To our knowledge, this is the first report showing the effects of IFN-alpha-2b on the prevention of the development of HFD-induced body weight gain and dyslipidemia through a mechanism that involves fatty acid oxidation and cholesterol decrease. | Cholesterol | interferon alpha | Mus musculus |