Title : IFN-α-2b treatment protects against diet-induced obesity and alleviates non-alcoholic fatty liver disease in mice.

Pub. Date : 2019 Sep 15

PMID : 31299271






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 IFN-alpha-2b-treated mice showed increased plasma cholesterol levels together with decreased hepatic cholesterol, both on chow and HF diets. Cholesterol interferon alpha Mus musculus
2 IFN-alpha-2b-treated mice showed increased plasma cholesterol levels together with decreased hepatic cholesterol, both on chow and HF diets. Cholesterol interferon alpha Mus musculus
3 Interestingly, mice on IFN-alpha-2b treatment secreted smaller VLDL particles highly enriched in cholesterol. Cholesterol interferon alpha Mus musculus
4 Mechanistically, we found that IFN-alpha-2b antiobesity effects were related to increased fatty acid oxidation; and its effects on cholesterol metabolism were due to both a decrease in the master cholesterogenic transcription factor SREBP-2 and in the rate limiting enzyme in cholesterol synthesis, HMGCR. Cholesterol interferon alpha Mus musculus
5 To our knowledge, this is the first report showing the effects of IFN-alpha-2b on the prevention of the development of HFD-induced body weight gain and dyslipidemia through a mechanism that involves fatty acid oxidation and cholesterol decrease. Cholesterol interferon alpha Mus musculus