Title : Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids.

Pub. Date : 2019 Aug 15

PMID : 31281020






1 Functional Relationships(s)
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1 Compound 10j, which is tacrine linked with pyrazolo[3,4-b]pyridine moiety by a six-carbon spacer, was the most potent acetylcholinesterase (AChE) with IC50 value of 0.125 muM. Carbon acetylcholinesterase (Cartwright blood group) Homo sapiens