Title : Beneficial effects of δ-tocotrienol against oxidative stress in osteoblastic cells: studies on the mechanisms of action.

Pub. Date : 2020 Aug

PMID : 31280345






2 Functional Relationships(s)
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1 delta-TT prevention of oxidative damage was completely removed by combined treatment with the specific inhibitors of PI3K/AKT (LY294002) and Nrf2 (ML385). tocotrienol, delta thymoma viral proto-oncogene 1 Mus musculus
2 CONCLUSIONS: The delta-TT protective effect against oxidative damage in MC3T3-E1 cells is due to a reduction of intracellular ROS levels and an increase of the GSH/GSSG ratio, and involves an interaction between the PI3K/Akt-Nrf2 signaling pathways. tocotrienol, delta thymoma viral proto-oncogene 1 Mus musculus