Title : Antagonistic effect of vitamin E on nAl2O3-induced exacerbation of Th2 and Th17-mediated allergic asthma via oxidative stress.

Pub. Date : 2019 Sep

PMID : 31277021






1 Functional Relationships(s)
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1 Results revealed that nAl2O3 could increase ROS levels and decrease GSH levels in lung tissue, promote the increases of the T-IgE, TGF-beta, IL-1beta and IL-6 levels, stimulate the overexpression of transcription factors GATA-3 and RORgammat, decrease the levels of IFN-gamma and IL-10 and increase the levels of IL-4 and IL-17A, resulting in the imbalance of Th1/Th2 and Treg/Th17 immune responses. nal2o3 GATA binding protein 3 Mus musculus