Title : Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models.

Pub. Date : 2019 Sep 1

PMID : 31276662






2 Functional Relationships(s)
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1 Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
2 In vitro studies showed higher intrinsic toxicities of both oximes than 2-PAM for AChE. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens