Pub. Date : 2019 May
PMID : 31276102
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 2 | The Nrf2 transcription factor orchestrates cell-intrinsic protective antioxidant responses, and the peptide hormone hepcidin maintains systemic iron homeostasis, but is pathophysiologically decreased in haemochromatosis and beta-thalassaemia. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 3 | Here, we show that Nrf2 is activated by iron-induced, mitochondria-derived pro-oxidants and drives Bmp6 expression in liver sinusoid endothelial cells, which in turn increases hepcidin synthesis by neighbouring hepatocytes. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 4 | In Nrf2 knockout mice, the Bmp6-hepcidin response to oral and parenteral iron is impaired and iron accumulation and hepatic damage are increased. | Iron | hepcidin antimicrobial peptide | Mus musculus |
| 5 | Pharmacological activation of Nrf2 stimulates the Bmp6-hepcidin axis, improving iron homeostasis in haemochromatosis and counteracting the inhibition of Bmp6 by erythroferrone in beta-thalassaemia. | Iron | hepcidin antimicrobial peptide | Mus musculus |