Pub. Date : 2019 Jul
PMID : 31235912
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The human equilibrative nucleoside transporter 1 (hENT1), a member of the SLC29 family, plays crucial roles in adenosine signaling, cellular uptake of nucleoside for DNA and RNA synthesis, and nucleoside-derived anticancer and antiviral drug transport in humans. | Adenosine | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 2 | The human equilibrative nucleoside transporter 1 (hENT1), a member of the SLC29 family, plays crucial roles in adenosine signaling, cellular uptake of nucleoside for DNA and RNA synthesis, and nucleoside-derived anticancer and antiviral drug transport in humans. | Adenosine | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 3 | Despite its importance in human physiology and pharmacology, the molecular basis of hENT1-mediated adenosine transport and its inhibition by AdoRIs are limited, owing to the absence of structural information on hENT1. | Adenosine | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 4 | Combined with mutagenesis study, our structural analyses elucidate two distinct inhibitory mechanisms exhibited on hENT1 and provide insight into adenosine recognition and transport. | Adenosine | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 5 | Our studies provide a platform for improved pharmacological intervention of adenosine and nucleoside analog drug transport by hENT1. | Adenosine | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |