Pub. Date : 2019 Sep
PMID : 31229649
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Drosophila ZIP13 is posttranslationally regulated by iron-mediated stabilization. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 2 | Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 3 | Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 4 | Drosophila ZIP13 (dZIP13, CG7816/ZIP99C) belongs to the SLC39A family and is connected to iron homeostasis in the fruit fly. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 5 | In this study, we show that dZIP13 level is strongly regulated by iron. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 6 | In addition to a mild response to iron at the mRNA level, dZIP13 is strongly regulated at the protein level. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 7 | This posttranslational regulation by iron also happens when dZIP13 is expressed in the yeast Saccharomyces cerevisiae. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 8 | Iron functions to stabilize dZIP13. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 9 | Domain-swapping experiments between dZIP7 (CG10449/ Catsup) and dZIP13 suggest that the N-terminus of dZIP13 is necessary to mediate this iron regulatory process. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 10 | Domain-swapping experiments between dZIP7 (CG10449/ Catsup) and dZIP13 suggest that the N-terminus of dZIP13 is necessary to mediate this iron regulatory process. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 11 | Mutations of these potential iron binding sites at the N-terminus, as well as a likely iron binding site at the C-terminus of dZIP13, completely abolish the iron-dependent upregulation in the yeast and the fruit fly. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 12 | Mutations of these potential iron binding sites at the N-terminus, as well as a likely iron binding site at the C-terminus of dZIP13, completely abolish the iron-dependent upregulation in the yeast and the fruit fly. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 13 | Iron-responsiveness of dZIP13 is consistent with its key role in iron homeostasis. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 14 | Iron-responsiveness of dZIP13 is consistent with its key role in iron homeostasis. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |
| 15 | We speculate that this process of dZIP13 regulation, and that of IRE/IRP-controlled ferritin production, work together to better cope with iron repletion in the fly. | Iron | Zinc/iron regulated transporter-related protein 99C | Drosophila melanogaster |