Title : 2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotes Proliferation of Astrocyte Cells via the Akt/STAT3/Cyclin D1 Pathway.

Pub. Date : 2019 Apr

PMID : 31217064






4 Functional Relationships(s)
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1 2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotes Proliferation of Astrocyte Cells via the Akt/STAT3/Cyclin D1 Pathway. Polychlorinated Dibenzodioxins cyclin D1 Homo sapiens
2 The exposure to TCDD resulted in the upregulation in the expression levels of phosphorylated protein kinase B (p-Akt), phosphorylated STAT3, and cyclin D1 in a dose- and time-dependent manner. Polychlorinated Dibenzodioxins cyclin D1 Homo sapiens
3 The inhibition of Akt expression with LY294002 or STAT3 expression with AG490 abolished the TCDD-induced cyclin D1 upregulation and cell proliferation. Polychlorinated Dibenzodioxins cyclin D1 Homo sapiens
4 CONCLUSION: TCDD exposure promotes the proliferation of astrocyte cells via the Akt/STAT3/cyclin D1 pathway, leading to astrogliosis. Polychlorinated Dibenzodioxins cyclin D1 Homo sapiens