Title : MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer.

Pub. Date : 2019 Jun 18

PMID : 31215481






3 Functional Relationships(s)
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1 Furthermore, the expression of HR repair factors (Rad51 and BRCA1) induced by doxorubicin was detected by Western blot and immunofluorescent staining in H446AR cells transfected with miR-7-5p mimic. Doxorubicin BRCA1 DNA repair associated Homo sapiens
2 MiR-7-5p impeded Dox-induced HR repair by inhibiting the expression of HR repair factors (Rad51 and BRCA1) that resulted in resensitizing SCLC cells to doxorubicin. Doxorubicin BRCA1 DNA repair associated Homo sapiens
3 MiR-7-5p impeded Dox-induced HR repair by inhibiting the expression of HR repair factors (Rad51 and BRCA1) that resulted in resensitizing SCLC cells to doxorubicin. Doxorubicin BRCA1 DNA repair associated Homo sapiens