Title : Conformational Cycling within the Closed State of Grp94, an Hsp90-Family Chaperone.

Pub. Date : 2019 Aug 9

PMID : 31202885






2 Functional Relationships(s)
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1 Under ATP turnover conditions, Grp94 populates two distinct closed states, a relatively static ATP/ATP closed state that adopts one conformation, and a dynamic ATP/ADP closed state that can adopt two conformations. Adenosine Diphosphate heat shock protein 90 beta family member 1 Homo sapiens
2 We constructed a Grp94 heterodimer with one arm that is catalytically dead, to extend the lifetime of the ATP/ADP state by preventing hydrolysis of the second ATP. Adenosine Diphosphate heat shock protein 90 beta family member 1 Homo sapiens