Title : Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death.

Pub. Date : 2019 Jun 13

PMID : 31196210






1 Functional Relationships(s)
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1 Combination treatment with curcumin and gefitinib markedly downregulated EGFR activity through suppressing Sp1 and blocking interaction of Sp1 and HADC1, and markedly suppressed receptor tyrosine kinases as well as ERK/MEK and AKT/S6K pathways in the resistant NSCLC cells. Gefitinib AKT serine/threonine kinase 1 Homo sapiens