Pub. Date : 2019 Jun 13
PMID : 31196146
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation. | Lysine | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | Here, we demonstrate that cardiac glycoside proscillaridin A specifically targets MYC overexpressing leukemia cells and leukemia stem cells by causing MYC degradation, epigenetic reprogramming and leukemia differentiation through loss of lysine acetylation. | Lysine | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |