Title : 3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation.

Pub. Date : 2019 Sep 15

PMID : 31185411






1 Functional Relationships(s)
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1 Following our previous work related to the modification of the hydrogen bond network between alpha-GalCer and CD1d, we have now focused our attention on the synthesis of 3-deoxy-3,3-difluoro- and 3,4-dideoxy-3,3,4,4-tetrafluoro-alpha-GalCer analogues, and studied their ability to stimulate human iNKT cells. Hydrogen CD1d molecule Homo sapiens