Title : Bupivacaine at clinically relevant concentrations induces toxicity in human intervertebral disc cells via the induction of autophagy in vitro.

Pub. Date : 2019 Jul

PMID : 31180558






2 Functional Relationships(s)
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1 Additionally, bupivacaine inhibited protein kinase B (Akt)/mammalian target of rapamycin (mTOR)/S6 kinase (S6K) signaling, which is a negative regulator of autophagic activity. Bupivacaine AKT serine/threonine kinase 1 Homo sapiens
2 The findings indicated that application of clinically relevant concentrations of bupivacaine upregulated autophagic activity via inhibition of Akt/mTOR/S6K signaling. Bupivacaine AKT serine/threonine kinase 1 Homo sapiens