Title : Novel Insights into Gallium's Mechanism of Therapeutic Action: A DFT/PCM Study of the Interaction between Ga3+ and Ribonucleotide Reductase Substrates.

Pub. Date : 2019 Jul 5

PMID : 31177779






2 Functional Relationships(s)
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1 Recently, another hypothesis for the Ga3+ curative effect has been put forward: the metal cation can deactivate the enzyme by entrapping its substrates (nucleotide diphosphates; NDPs) into Ga3+-NDP complexes, lowering the free substrate levels in the cell. N,N-di-n-propylserotonin succinyl-CoA:glutarate-CoA transferase Homo sapiens
2 Recently, another hypothesis for the Ga3+ curative effect has been put forward: the metal cation can deactivate the enzyme by entrapping its substrates (nucleotide diphosphates; NDPs) into Ga3+-NDP complexes, lowering the free substrate levels in the cell. N,N-di-n-propylserotonin succinyl-CoA:glutarate-CoA transferase Homo sapiens