Title : Enhanced cellular cholesterol efflux by naringenin is mediated through inhibiting endoplasmic reticulum stress - ATF6 activity in macrophages.

Pub. Date : 2019 Oct

PMID : 31176760






4 Functional Relationships(s)
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1 Enhanced cellular cholesterol efflux by naringenin is mediated through inhibiting endoplasmic reticulum stress - ATF6 activity in macrophages. Cholesterol activating transcription factor 6 Mus musculus
2 Clinical data revealed that ATF6 expression was associated with plasma cholesterol level. Cholesterol activating transcription factor 6 Mus musculus
3 Naringenin-induced cholesterol efflux was modulated by treatment with ER stress inhibitor 4-phenylbutyric acid, inducer tunicamycin and ATF6 overexpression in RAW264.7 and/or THP-1 cells, which suggested the naringenin functions were mediated through inhibiting ER stress-ATF6 pathway. Cholesterol activating transcription factor 6 Mus musculus
4 We concluded naringenin as a regulator for cholesterol efflux, and the regulation was mediated by ATF6 branch of ER stress and PI3K/AKT pathway. Cholesterol activating transcription factor 6 Mus musculus