Title : Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity.

Pub. Date : 2019 Aug 1

PMID : 31163215






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity. 7-hydroxycoumarin cytochrome P450 family 2 subfamily A member 6 Homo sapiens
2 Compared with coumarin, 7-hydroxycoumarin could serve as a better hit for developing CYP2A6 inhibitors. 7-hydroxycoumarin cytochrome P450 family 2 subfamily A member 6 Homo sapiens
3 In this study, a series of 7-hydroxycoumarin and its structural analogues were collected to study their structure-activity relationship (SAR) and isoform selectivity for inhibiting CYP2A6. 7-hydroxycoumarin cytochrome P450 family 2 subfamily A member 6 Homo sapiens