Pub. Date : 2019 Aug 15
PMID : 31160492
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 2 | The Poly(C) Motif in the Proximal Promoter Region of the D Site-Binding Protein Gene (Dbp) Drives Its High-Amplitude Oscillation. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 3 | Here, we demonstrated that the poly(C) motif within the Dbp proximal promoter, in addition to an E-box element, provoked transcriptional activation. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 4 | Furthermore, we generated a cell line with poly(C) deleted to demonstrate the endogenous effect of the poly(C) motif within the Dbp promoter. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 5 | Next, assay for transposase-accessible chromatin (ATAC)-quantitative PCR (qPCR) showed that the poly(C) motif induced greater chromatin accessibility within the region of the Dbp promoter. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 6 | Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 7 | Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 8 | Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 9 | Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 10 | Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |
| 11 | Finally, we determined that the oscillation amplitude of endogenous Dbp mRNA of the cell line with poly(C) deleted was decreased, which affected the oscillation of other clock genes that are controlled by Dbp Taken together, our results provide new insights into the function of the poly(C) motif as a novel cis-acting element of Dbp, along with its significance in the regulation of circadian rhythms. | Poly C | D-box binding PAR bZIP transcription factor | Homo sapiens |