Title : Reduced clearance rate of thyroxine-binding globulin (TBG) with increased sialylation: a mechanism for estrogen-induced elevation of serum TBG concentration.

Pub. Date : 1987 Oct

PMID : 3116030






4 Functional Relationships(s)
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1 Hyperestrogenemic states, including pregnancy, cause an increase in serum T4-binding globulin (TBG) concentrations and an increase in the proportion of TBG molecules with greater anodal mobility on isoelectric focusing, indicating greater sialic acid content. N-Acetylneuraminic Acid serpin family A member 7 Homo sapiens
2 These results indicate that the rate of in vivo metabolism of TBG is dependent on its sialic acid content. N-Acetylneuraminic Acid serpin family A member 7 Homo sapiens
3 The increased proportion of TBG molecules with higher sialic acid content thus contributes to the increase in the serum TBG concentration in hyperestrogenemic states. N-Acetylneuraminic Acid serpin family A member 7 Homo sapiens
4 The increased proportion of TBG molecules with higher sialic acid content thus contributes to the increase in the serum TBG concentration in hyperestrogenemic states. N-Acetylneuraminic Acid serpin family A member 7 Homo sapiens