Title : Epigenetic drugs as new therapy for tumor necrosis factor-α-compromised bone healing.

Pub. Date : 2019 Oct

PMID : 31152802






2 Functional Relationships(s)
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1 NMP and DMA pre-treatment recovered TNFalpha-inhibited expression of essential osteoblastic genes, Alp, Runx2, and Osterix as well as mineralization in multipotent stem cells, but not in pre-osteoblasts and calvarial osteoblasts. dimethylacetamide tumor necrosis factor Homo sapiens
2 TNFalpha largely abrogated BMP-promoted growth of mineralized bone while pre-treatment of NMP and DMA prevented the deleterious effect of TNFalpha. dimethylacetamide tumor necrosis factor Homo sapiens