Pub. Date : 2019 May 30
PMID : 31150623
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. | Sphingolipids | ceramide synthase 6 | Homo sapiens |
| 2 | Here we demonstrate that the C16:0 sphingolipid synthesizing ceramide synthases, CerS5 and CerS6, affect distinct sphingolipid pools and that abrogation of CerS6 but not of CerS5 protects from obesity and insulin resistance. | Sphingolipids | ceramide synthase 6 | Homo sapiens |
| 3 | Here we demonstrate that the C16:0 sphingolipid synthesizing ceramide synthases, CerS5 and CerS6, affect distinct sphingolipid pools and that abrogation of CerS6 but not of CerS5 protects from obesity and insulin resistance. | Sphingolipids | ceramide synthase 6 | Homo sapiens |
| 4 | Here we demonstrate that the C16:0 sphingolipid synthesizing ceramide synthases, CerS5 and CerS6, affect distinct sphingolipid pools and that abrogation of CerS6 but not of CerS5 protects from obesity and insulin resistance. | Sphingolipids | ceramide synthase 6 | Homo sapiens |
| 5 | We identify proteins that specifically interact with C16:0 sphingolipids derived from CerS5 or CerS6. | Sphingolipids | ceramide synthase 6 | Homo sapiens |
| 6 | Here, only CerS6-derived C16:0 sphingolipids bind the mitochondrial fission factor (Mff). | Sphingolipids | ceramide synthase 6 | Homo sapiens |
| 7 | Our experiments reveal an unprecedented specificity of sphingolipid signaling depending on specific synthesizing enzymes, provide a mechanistic link between hepatic lipid deposition and mitochondrial fragmentation in obesity, and define the CerS6-derived sphingolipid/Mff interaction as a therapeutic target for metabolic diseases. | Sphingolipids | ceramide synthase 6 | Homo sapiens |
| 8 | Our experiments reveal an unprecedented specificity of sphingolipid signaling depending on specific synthesizing enzymes, provide a mechanistic link between hepatic lipid deposition and mitochondrial fragmentation in obesity, and define the CerS6-derived sphingolipid/Mff interaction as a therapeutic target for metabolic diseases. | Sphingolipids | ceramide synthase 6 | Homo sapiens |