Title : Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis.

Pub. Date : 2019 Jul 1

PMID : 31142603






2 Functional Relationships(s)
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1 Our data show that metformin increased IL-10 and IDO expression in Ad-hMSCs and decreased high-mobility group box 1 protein, IL-1beta, and IL-6 expression. Metformin interleukin 1 beta Rattus norvegicus
2 In cocultures, metformin-stimulated Ad-hMSCs inhibited the mRNA expression of RUNX2, COL X, VEGF, MMP1, MMP3, and MMP13 in IL-1beta-stimulated OA chondrocytes and increased the expression of TIMP1 and TIMP3. Metformin interleukin 1 beta Rattus norvegicus