Title : High-glucose administration induces glucose intolerance in mice: a critical role of toll-like receptor 4.

Pub. Date : 2019 May

PMID : 31138952






3 Functional Relationships(s)
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1 Moreover, 20 g/kg glucose load also impaired glucose-induced GLP-1 secretion in wild-type and TLR4 knockout mice. Glucose glucagon Mus musculus
2 Moreover, 20 g/kg glucose load also impaired glucose-induced GLP-1 secretion in wild-type and TLR4 knockout mice. Glucose glucagon Mus musculus
3 Our results indicate that high-glucose load leads to glucose intolerance with insulin resistance through impairment of GLP-1 secretion, increase of blood glucose levels via activating TLR4 and increasing levels of IL-6 and TNF-alpha in mice. Glucose glucagon Mus musculus