Title : [Demonstration of synergy between the factor stimulating granulocytes and macrophages colonies and interleukin-I for the stimulation of prostaglandin E2 synthesis by bone marrow cells].

Pub. Date : 1987

PMID : 3113689






4 Functional Relationships(s)
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1 Conditioned medium from P388 D1 cell line containing interleukin 1 (IL-1) and granulocyte macrophage colony stimulating factor (GM-CSF) can stimulate prostaglandin E2 (PGE2) production by murine bone marrow cells. Dinoprostone interleukin 1 complex Mus musculus
2 Conditioned medium from P388 D1 cell line containing interleukin 1 (IL-1) and granulocyte macrophage colony stimulating factor (GM-CSF) can stimulate prostaglandin E2 (PGE2) production by murine bone marrow cells. Dinoprostone interleukin 1 complex Mus musculus
3 However, the simultaneous addition of IL-1 and GM-CSF markedly increases PGE2 production. Dinoprostone interleukin 1 complex Mus musculus
4 Thus, the ability of P388 D1 CM to stimulate PGE2 synthesis by bone marrow cells appears to result from a synergistic action between GM-CSF and IL-1. Dinoprostone interleukin 1 complex Mus musculus