Pub. Date : 2019 Jun 21
PMID : 31134799
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The scaffolds of polyketides are constructed via assembly of extender units based on malonyl-CoA and its derivatives that are substituted at the C2-position with diverse chemical functionality. | Polyketides | HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 | Mus musculus |
| 2 | Yet, a biosensor for the detection of malonyl-CoA derivatives has yet to be reported, severely restricting the application of high-throughput synthetic biology approaches to engineering extender unit biosynthesis and limiting the ability to dynamically regulate the biosynthesis of polyketide products that are dependent on such alpha-carboxyacyl-CoAs. | Polyketides | HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 | Mus musculus |
| 3 | This FapR promiscuity proved sufficient for the detection of the polyketide extender unit methylmalonyl-CoA in E. coli, providing the first reported genetically encoded biosensor for this important metabolite. | Polyketides | HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 | Mus musculus |