Title : PD-L1 is a double-edged sword in colorectal cancer: the prognostic value of PD-L1 depends on the cell type expressing PD-L1.

Pub. Date : 2019 Jul

PMID : 31129768






3 Functional Relationships(s)
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1 The number of patients with PD-L1 expression on TCs, stromal TIICs and intraepithelial TIICs was 13 (5.5%), 64 (26.9%) and 45 (18.9%), respectively. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide CD274 molecule Homo sapiens
2 PD-L1-expressing TCs were an independent marker of poor prognosis [hazard ratio (HR) = 3.387, P = 0.003], and PD-L1-expressing stromal TIICs were an independent marker of good prognosis (HR = 0.551, P < 0.001). 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide CD274 molecule Homo sapiens
3 CONCLUSIONS: PD-L1-expressing TCs were a marker of poor prognosis; in contrast, PD-L1-expressing TIICs were a marker of good prognosis. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide CD274 molecule Homo sapiens