Pub. Date : 2019 Aug
PMID : 31121484
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SNHG14 confers gefitinib resistance in non-small cell lung cancer by up-regulating ABCB1 via sponging miR-206-3p. | Gefitinib | small nucleolar RNA host gene 14 | Homo sapiens |
| 2 | The present study aims to investigate the functions of SNHG14 in gefitinib resistance and gain insight into the underlying molecular mechanisms. | Gefitinib | small nucleolar RNA host gene 14 | Homo sapiens |
| 3 | In the present study, we found that SNHG14 expression was elevated and miR-206-3p expression was decreased in gefitinib-resistant NSCLC tumor tissues and cells. | Gefitinib | small nucleolar RNA host gene 14 | Homo sapiens |
| 4 | Functionally, SNHG14 overexpression increased gefitinib resistance by promoting cell viability, lowering apoptosis and enhancing colony forming ability, while SNHG14 knockdown reduced gefitinib resistance in NSCLC cells. | Gefitinib | small nucleolar RNA host gene 14 | Homo sapiens |
| 5 | Functionally, SNHG14 overexpression increased gefitinib resistance by promoting cell viability, lowering apoptosis and enhancing colony forming ability, while SNHG14 knockdown reduced gefitinib resistance in NSCLC cells. | Gefitinib | small nucleolar RNA host gene 14 | Homo sapiens |
| 6 | Moreover, depletion of SNHG14 enhanced the sensitivity of NSCLC cells to gefitinib in vivo. | Gefitinib | small nucleolar RNA host gene 14 | Homo sapiens |
| 7 | Together, SNHG14 confers gefitinib resistance in NSCLC by regulating miR-206-3p/ABCB1 pathway, contributing to a better understanding of SNHG14 in acquired resistance and elucidating a candidate target to improve treatment response of NSCLC patients. | Gefitinib | small nucleolar RNA host gene 14 | Homo sapiens |