Title : Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4).

Pub. Date : 2019 Dec

PMID : 31101938






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Both transporters mediate L-lactate transport, but, although hMCT1 also transports L-5-oxoproline (L-OPro), this compound is minimally transported by hMCT4. Pyrrolidonecarboxylic Acid solute carrier family 16 member 1 Homo sapiens
2 Both transporters mediate L-lactate transport, but, although hMCT1 also transports L-5-oxoproline (L-OPro), this compound is minimally transported by hMCT4. Pyrrolidonecarboxylic Acid solute carrier family 16 member 1 Homo sapiens