Title : Role of Connexin 36 in Autoregulation of Oxytocin Neuronal Activity in Rat Supraoptic Nucleus.

Pub. Date : 2019 Jan-Dec

PMID : 31091986






2 Functional Relationships(s)
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1 In brain slices from lactating rats, application of quinine (0.1 mM), a selective blocker of Cx36, significantly reduced dye coupling among OT neurons as well as the discharge/firing frequency of spikes/action potentials and their amplitude, and transiently depolarized the membrane potential of OT neurons in whole-cell patch-clamp recordings. Quinine gap junction protein, delta 2 Rattus norvegicus
2 Lastly, Western blotting analysis revealed that the presence of combined, but not alone, quinine and OT significantly reduced the amount of Cx36 in the SON. Quinine gap junction protein, delta 2 Rattus norvegicus