Title : PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

Pub. Date : 2019 May 14

PMID : 31091439






1 Functional Relationships(s)
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1 Our work uncovers an allosteric function of PIP4Ks in suppressing PIP5K-mediated PI(4,5)P2 synthesis and insulin-dependent conversion to PI(3,4,5)P3 and suggests that the pharmacological depletion of PIP4K enzymes could represent a strategy for enhancing insulin signaling. pi(4,5)p2 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens